Letrozol STADA 2.5mg Filmtabletten

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Generally, adverse reactions were mild to moderately severe and mainly related to suppression of estrogen synthesis. Determination of the frequency of adverse reactions: very common ( >10%), common (1-10%), sometimes (0.1-1%), rare (0.01-0.1%), very rare ( less than 0.01%), including isolated reports Digestive system: often – nausea, vomiting, dyspepsia, constipation, diarrhoea . sometimes – abdominal pain, stomatitis, dry mouth, increased activity of liver enzymes. Nervous system: often – headache, dizziness, depression . sometimes – anxiety, nervousness, irritability, somnolence, insomnia, memory impairment, dysesthesia, paresthesia, hypoesthesia, episodes of cerebral circulation disorders. Hematopoiesis: sometimes – leukopenia. Cardiovascular system: sometimes – palpitations, tachycardia, thrombophlebitis of superficial and deep veins, increased BP, CHD (angina pectoris, myocardial infarction, heart failure), thromboembolism. rarely – pulmonary embolism, arterial thrombosis, stroke. Respiratory system: sometimes – dyspnoea, cough. Dermatological reactions: often – alopecia, increased sweating, skin rash (including erythematous, maculo-papular, vesicular rash, psoriasis-like rashes) . sometimes – skin itching, dry skin, urticaria . very rare – angioedema, anaphylactic reactions. Musculoskeletal system: very often – arthralgia . often – myalgia, bone pain, osteoporosis, bone fractures, sometimes – arthritis. Sensory organs: sometimes – cataract, eye irritation, blurred vision, taste disturbance. Urinary system: sometimes – increased urination, urinary tract infections. Reproductive system: sometimes – vaginal bleeding, vaginal discharge, vaginal dryness, pain in the mammary glands. Metabolism: often – increase in body weight, hypercholesterolaemia, anorexia, increased appetite. sometimes – decrease in body weight, thirst. Other: very often – hot flashes (hot flashes) . often – increased fatigue, asthenia, malaise, peripheral edema . sometimes – hyperthermia (pyrexia), dry mucous membranes, generalised oedema, pain in tumour foci.