Letrozol Heumann 2,5 mg

Description

Directions for use and dosage

• Intravenously, irrespective of meals.
• The recommended dose of Letrozole is 2.5 mg once daily, long-term. As prolonged adjuvant therapy, treatment should be continued for 5 years (not longer than 5 years).
• Letrozole should be discontinued if signs of disease progression occur.
• No dose adjustment is required in elderly patients.
• No dose adjustment is required for hepatic or renal impairment (CK ≥10 ml/min). However, in cases of severe hepatic impairment (Child-Pugh class C), patients should be kept under constant observation.

Undesirable effects

• headache, dizziness, weakness, depression, increased fatigue (including weakness and anxiety)
• Nausea, vomiting, indigestion, constipation, diarrhoea, changes in appetite, decreased or increased body weight, hypercholesterolaemia, anorexia, thirst
• peripheral oedema
• leucorrhoea, vaginal bleeding, vaginal bleeding, breast pain
• skin rash (including erythematous and papular macular rash, vesicular rash, psoriasis-like rash), hot flashes, alopecia areata.
• dyspnoea, cough
• superficial and deep vein thrombophlebitis, tachycardia, increased blood pressure, thromboembolism.
• musculoskeletal pain (including shoulder, back, leg and bone pain), joint pain, muscle pain, osteoporosis, bone fractures
• increased sweating, thinning hair
• increased urination, urinary tract infections